GTP-γ-S

GTPγS (Guanosine 5'-[γ-thio]triphosphate) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS to couple with G- protein α, to study its effect on kinase activity. GTPγS acts as a component of lysis buffer[1][2][3][4].

Product Specifications

CAS Number

[37589-80-3]

Product Name Alternative

Guanosine 5'-[γ-thio]triphosphate

UNSPSC

12352005

Target

GLUT

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Others

Smiles

O[C@H]1[C@@H](O)[C@@H](N2C(NC(N)=NC3=O)=C3N=C2)O[C@H]1COP(O)(OP(OP(S)(O)=O)(O)=O)=O

Molecular Formula

C10H16N5O13P3S

Molecular Weight

539.25

References & Citations

[1]Julie G Hensler, et al. Differential Regulation of 5-HT1A Receptor-G Protein Interactions in Brain Following Chronic Antidepressant Administration. Neuropsychopharmacology. 2002 May;26 (5) :565-73. |[2]Li-Bin Liu, et al. Insulin recruits GLUT4 from distinct compartments via distinct traffic pathways with differential microtubule dependence in rat adipocytes. J Biol Chem. 2003 Aug 8;278 (32) :30157-69. doi: 10.1074/jbc.M301511200. |[3]Xufeng Wu, et al. Rab27a is an essential component of melanosome receptor for myosin Va. Mol Biol Cell. 2002 May;13 (5) :1735-49.|[4]Pilar Sánchez-Blázquez, et al. Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway. Cell Signal. 2009 Sep;21 (9) :1444-54.