IsoGTP (sodium)
IsoGTP (Isoguanosine-5'-O-triphosphate) sodium is an isomer of guanosine 5'-triphosphate and a phosphorylated form of Crotonoside (HY-N0071) . isoGTP sodium inhibits transcription and induces T to C mutations in a reverse transcriptase assay. isoGTP sodium is promising for research of substrate specificity of phosphofructokinase and mutT homolog 1 (MTH1) [1][2].
Product Specifications
Product Name Alternative
Isoguanosine-5'-O-triphosphate (sodium)
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=P(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C(N)NC(N=C32)=O)O1
Molecular Formula
C10H12N5Na4O14P3
Molecular Weight
611.11
References & Citations
[1]Kamiya H, et al. Mutagenic properties of oxidized GTP and ATP in in vitro transcription-reverse transcription. Nucleic Acids Symp Ser (Oxf) . 2006; (50) :99-100.|[2]Fujikawa K, et al. Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP. Nucleic Acids Res. 2001 Jan 15;29 (2) :449-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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