Purine riboside-5'-O-triphosphate (sodium)

Purine riboside-5'-O-triphosphate sodium, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate sodium inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM[1][2][3].

Product Specifications

CAS Number

[35892-95-6]

Product Name Alternative

PTP (tetrasodium)

UNSPSC

12352005

Target

CaMK; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

Related Pathways

Cell Cycle/DNA Damage; Neuronal Signaling

Field of Research

Metabolic Disease

Smiles

O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)N2C3=NC=NC=C3N=C2

Molecular Formula

C10H11N4Na4O13P3

Molecular Weight

580.09

References & Citations

[1]Kozlowska M, et al. ATP depletion, purine riboside triphosphate accumulation and rat thymocyte death induced by purine riboside. Toxicol Lett. 1999;104 (3) :171-181.|[2]Moore CL, et al. Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates. Biochemistry. 2004;43 (38) :12367-12374. |[3]Kwiatkowski AP, et al. Mapping of the adenosine 5'-triphosphate binding site of type II calmodulin-dependent protein kinase. Biochemistry. 1987;26 (24) :7636-7640.