Tetrandrine
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.
Product Specifications
CAS Number
518-34-3
Product Name Alternative
NSC-77037; d-Tetrandrine
UNSPSC
12352005
Hazard Statement
H300
Target
Calcium Channel; Parasite; Potassium Channel
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Purity
99.90
Solubility
DMSO : 5 mg/mL (ultrasonic; warming)
Smiles
COC1=CC(CCN(C)[C@@]2([H])CC3=CC(O4)=C(OC)C=C3)=C2C(OC5=C(OC)C=C6C([C@]([H])(CC7=CC=C4C=C7)N(C)CC6)=C5)=C1OC
Molecular Formula
C38H42N2O6
Molecular Weight
622.75
Precautions
H300
References & Citations
[1]Wang G, et al. Tetrandrine blocks a slow, large-conductance, Ca (2+) -activated potassium channel besides inhibiting a non-inactivating Ca2+ current in isolated nerve terminals of the rat neurohypophysis. Pflugers Arch. 1992 Sep;421 (6) :558-65.|[2]Zhang Z, et al. The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells. J Exp Clin Cancer Res. 2018 Jan 15;37 (1) :7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
494632 100 µL
TRIM9 (E3 Ubiquitin-protein Ligase TRIM9, Tripartite Motif Containing 9)
Sign In for Pricing
View Details