Tetrandrine
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.
Product Specifications
CAS Number
518-34-3
Product Name Alternative
NSC-77037; d-Tetrandrine
UNSPSC
12352005
Hazard Statement
H300
Target
Calcium Channel; Parasite; Potassium Channel
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Purity
99.90
Solubility
DMSO : 5 mg/mL (ultrasonic; warming)
Smiles
COC1=CC(CCN(C)[C@@]2([H])CC3=CC(O4)=C(OC)C=C3)=C2C(OC5=C(OC)C=C6C([C@]([H])(CC7=CC=C4C=C7)N(C)CC6)=C5)=C1OC
Molecular Formula
C38H42N2O6
Molecular Weight
622.75
Precautions
H300
References & Citations
[1]Wang G, et al. Tetrandrine blocks a slow, large-conductance, Ca (2+) -activated potassium channel besides inhibiting a non-inactivating Ca2+ current in isolated nerve terminals of the rat neurohypophysis. Pflugers Arch. 1992 Sep;421 (6) :558-65.|[2]Zhang Z, et al. The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells. J Exp Clin Cancer Res. 2018 Jan 15;37 (1) :7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Available Sizes
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