Tetrandrine

Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.

Product Specifications

CAS Number

[518-34-3]

Product Name Alternative

NSC-77037; d-Tetrandrine

UNSPSC

12352005

Hazard Statement

H300

Target

Calcium Channel; Parasite; Potassium Channel

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Purity

99.90

Solubility

DMSO : 5 mg/mL (ultrasonic; warming)

Smiles

COC1=CC(CCN(C)[C@@]2([H])CC3=CC(O4)=C(OC)C=C3)=C2C(OC5=C(OC)C=C6C([C@]([H])(CC7=CC=C4C=C7)N(C)CC6)=C5)=C1OC

Molecular Formula

C38H42N2O6

Molecular Weight

622.75

Precautions

H300

References & Citations

[1]Wang G, et al. Tetrandrine blocks a slow, large-conductance, Ca (2+) -activated potassium channel besides inhibiting a non-inactivating Ca2+ current in isolated nerve terminals of the rat neurohypophysis. Pflugers Arch. 1992 Sep;421 (6) :558-65.|[2]Zhang Z, et al. The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells. J Exp Clin Cancer Res. 2018 Jan 15;37 (1) :7.