Tesmilifene (hydrochloride)
Tesmilifene hydrochloride is an antihistamine agent and a chemical sensitizer. Tesmilifene hydrochloride targets cytochrome P450, exhibits hormonal effects on DNA synthesis in MCF-7 cells, and stimulates the tumor growth in mouse/rat models. Tesmilifene hydrochloride overcomes multidrug resistance[1].
Product Specifications
CAS Number
[92981-78-7]
UNSPSC
12352005
Target
Cytochrome P450
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1.Cl
Molecular Formula
C19H26ClNO
Molecular Weight
319.87
References & Citations
[1]Brandes LJ. N, N-diethyl-2-[4- (phenylmethyl) phenoxy] ethanamine (DPPE; tesmilifene), a chemopotentiating agent with hormetic effects on DNA synthesis in vitro, may improve survival in patients with metastatic breast cancer. Hum Exp Toxicol. 2008 Feb;27 (2) :143-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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