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Tesmilifene (hydrochloride)

Tesmilifene hydrochloride is an antihistamine agent and a chemical sensitizer. Tesmilifene hydrochloride targets cytochrome P450, exhibits hormonal effects on DNA synthesis in MCF-7 cells, and stimulates the tumor growth in mouse/rat models. Tesmilifene hydrochloride overcomes multidrug resistance[1].

Product Specifications

CAS Number

[92981-78-7]

UNSPSC

12352005

Target

Cytochrome P450

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1.Cl

Molecular Formula

C19H26ClNO

Molecular Weight

319.87

References & Citations

[1]Brandes LJ. N, N-diethyl-2-[4- (phenylmethyl) phenoxy] ethanamine (DPPE; tesmilifene), a chemopotentiating agent with hormetic effects on DNA synthesis in vitro, may improve survival in patients with metastatic breast cancer. Hum Exp Toxicol. 2008 Feb;27 (2) :143-7.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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