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Sp-ATPαS (tetrasodium)

Sp-ATPαS tetrasodium is a thiophosphonate analogue of ATP. Sp-ATPαS tetrasodium is a competitive antagonist of the human P2Y1 receptor and can inhibit the calcium signal induced by ADP. Sp-ATPαS tetrasodium has higher metabolic stability than ATP. Sp-ATPαS tetrasodium can be used to study the binding mode of metal-nucleotide in enzymatic reactions[1].

Product Specifications

UNSPSC

12352005

Target

P2Y Receptor

Related Pathways

GPCR/G Protein

Field of Research

Others

Smiles

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1CO[P@@](OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(S[Na])=O

Molecular Formula

C10H12N5Na4O12P3S

Molecular Weight

611.17

References & Citations

[1]Connolly BA, Eckstein F. S-Methylated nucleoside phosphorothioates as probes of enzyme metal X nucleotide binding sites. Biochemistry. 1982 Nov 23;21 (24) :6158-67. |[2]Léon C, et al. The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells. FEBS Lett. 1997 Feb 10;403 (1) :26-30.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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