Sp-dCTPαS (tetrasodium)
Sp-dCTPαS tetrasodium is a sulfur-containing isomer of dGTP. Sp-dCTPαS tetrasodium inhibits SAMHD1 triphosphohydrolase activity with a Ki of 6.3 μM[1].
Product Specifications
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Infection
Smiles
O[C@H]1C[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1CO[P@@](OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(S[Na])=O
Molecular Formula
C9H12N3Na4O12P3S
Molecular Weight
571.15
References & Citations
[1]Morris ER, et al. Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers. Biochemistry. 2021 Jun 1;60 (21) :1682-1698.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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