Sp-dGTPαS (tetrasodium)

Sp-dGTPαS tetrasodium is a sulfur-containing isomer of dGTP (HY-138616) . Sp-dGTPαS tetrasodium inhibits SAMHD1 triphosphohydrolase activity with a Ki of 820 nM[1].

Product Specifications

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

O[C@H]1C[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O[C@@H]1CO[P@@](OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(S[Na])=O

Molecular Formula

C10H12N5Na4O12P3S

Molecular Weight

611.17

References & Citations

[1]Morris ER, et al. Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers. Biochemistry. 2021 Jun 1;60 (21) :1682-1698.