Rp-dUTPαS (tetrasodium)

Rp-dUTPαS (tetrasodium) is an isomer of the sulfur-containing nucleoride dUTP-α-S and an agonist of the purinergic P2Y2 receptor. Rp-dUTPαS (tetrasodium) selectively induces inositol phosphate accumulation in P2Y2-expressing 1321N1 cells with an EC50 of 12.5 μM[1].

Product Specifications

UNSPSC

12352005

Target

P2Y Receptor

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=[P@](OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(OC[C@@H]1[C@@H](O)C[C@H](N2C=CC(NC2=O)=O)O1)S[Na]

Molecular Formula

C9H11N2Na4O13P3S

Molecular Weight

572.13

References & Citations

[1]Jacobson, K. A., et al., (2006) . Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Biochemical pharmacology, 71 (4), 540–549.