Sp-TTPαS (tetrasodium)

Sp-TTPαS tetrasodium is a competitivesterile alpha motif and HD domain containing protein 1 (SAMHD1) hydrolysis inhibitor. Sp-TTPαS tetrasodium competitively inhibits SAMHD1 triphosphohydrolase activity with a Ki value of 46 µM[1].

Product Specifications

UNSPSC

12352005

Target

HIV

Related Pathways

Anti-infection

Field of Research

Infection; Inflammation/Immunology

Smiles

O[C@H]1C[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO[P@@](OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(S[Na])=O

Molecular Formula

C10H13N2Na4O13P3S

Molecular Weight

586.16

References & Citations

[1]Morris ER, et al. Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers. Biochemistry. 2021 Jun 1;60 (21) :1682-1698.