Uridine 5'-O-thiodiphosphate (trisodium)
Uridine 5'-O-thiodiphosphate (trisodium) (UDP-β-S (trisodium) ) is a purinergic P2Y6 receptor agonist. Uridine 5'-O-thiodiphosphate (trisodium) selectively induces accumulation of inositol phosphates in 1321N1 cells expressing P2Y6 receptors (EC50 = 28 nM) . Uridine 5'-O-thiodiphosphate (trisodium) induces DNA synthesis in rat aortic smooth muscle cells[1].
Product Specifications
Product Name Alternative
UDP-β-S (trisodium)
UNSPSC
12352005
Target
DNA/RNA Synthesis; P2Y Receptor
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein
Field of Research
Cardiovascular Disease
Smiles
O[C@H]1[C@@H](O)[C@H](N2C=CC(NC2=O)=O)O[C@@H]1COP(OP(O[Na])(S[Na])=O)(O[Na])=O
Molecular Formula
C9H11N2Na3O11P2S
Molecular Weight
486.17
References & Citations
[1]Hou M, et al. UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y (6) receptors. Am J Physiol Heart Circ Physiol. 2002 Feb;282 (2) :H784-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y6 Receptor
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