Uridine-5'-O- (3-thiotriphosphate) (tetrasodium)
Uridine-5'-O- (3-thiotriphosphate) (UTPγS) tetrasodium, a stable analogue of Uridine triphosphate (UTP) , is a potent agonist of the P2Y2 and P2Y4 receptors with increased metabolic stability. Uridine-5'-O- (3-thiotriphosphate) tetrasodium stimulates inositol phosphate formation in human 1321N1 astrocytoma cells stably expressing the phospholipase C-coupled human P2U-purinoceptor (EC50 = 240 nM)[2][3].
Product Specifications
Product Name Alternative
UTPγS (tetrasodium)
UNSPSC
12352005
Target
P2Y Receptor
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease; Neurological Disease
Smiles
O=P(OP(OP(S[Na])(O[Na])=O)(O[Na])=O)(OC[C@H]1O[C@@H](N2C(NC(C=C2)=O)=O)[C@H](O)[C@@H]1O)O[Na]
Molecular Formula
C9H11N2Na4O14P3S
Molecular Weight
588.13
References & Citations
[1]Anna-Karin Wihlborg, et al. Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction. Circ Res. 2006 Apr 14;98 (7) :970-6.|[2]Malin Malmsjö, et al. The stable pyrimidines UDPβS and UTPγS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery. Br J Pharmacol. 2000 Sep;131 (1) :51-6.|[3]Lazarowski ER, et al. Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors. Br J Pharmacol. 1996 Jan;117 (1) :203-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y2 Receptor
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