Florzolotau
Florzolotau (APN1607) is a positron emission tomography (PET) ligand that can be used to detect Alzheimer's disease (AD) and other tau proteinopathies. Its binding sites are located in the β-helix of the paired helical filaments (PHFs) and straight filaments (SFs) of the tau protein, as well as in the C-shaped cavity of the SFs. In addition, APN-1607 can bind to the intraneuronal inclusions in Alzheimer's disease (AD), primary age-related tauopathy (PART), and posterior cortical atrophy (PCA) . Florzolotau is expected to be used in PET imaging research of neurological diseases, especially tau proteinopathies[1].
Product Specifications
CAS Number
1565797-16-1
Product Name Alternative
APN1607; PM-PBB3
UNSPSC
12352005
Target
Biochemical Assay Reagents
Related Pathways
Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
OC(COC1=CC=C2N=C(/C=C/C=C/C3=CC=C(NC)N=C3)SC2=C1)CF
Molecular Formula
C20H20FN3O2S
Molecular Weight
385.46
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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