Florzolotau

Florzolotau (APN1607) is a positron emission tomography (PET) ligand that can be used to detect Alzheimer's disease (AD) and other tau proteinopathies. Its binding sites are located in the β-helix of the paired helical filaments (PHFs) and straight filaments (SFs) of the tau protein, as well as in the C-shaped cavity of the SFs. In addition, APN-1607 can bind to the intraneuronal inclusions in Alzheimer's disease (AD), primary age-related tauopathy (PART), and posterior cortical atrophy (PCA) . Florzolotau is expected to be used in PET imaging research of neurological diseases, especially tau proteinopathies[1].

Product Specifications

CAS Number

[1565797-16-1]

Product Name Alternative

APN1607; PM-PBB3

UNSPSC

12352005

Target

Biochemical Assay Reagents

Related Pathways

Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

OC(COC1=CC=C2N=C(/C=C/C=C/C3=CC=C(NC)N=C3)SC2=C1)CF

Molecular Formula

C20H20FN3O2S

Molecular Weight

385.46

References & Citations

[1]Shi Y, et al. Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol. 2021 May;141 (5) :697-708. doi: 10.1007/s00401-021-02294-3. Epub 2021 Mar 16. Erratum in: Acta Neuropathol. 2021 Jun;141 (6) :983.