NTRC-808
NTRC-808 is a nonpeptide selective GPCR neurotensin receptor type 2 (NTS2) partial agonist with an EC50 of 14 nM and Ki of 88 nM. NTRC-808 has higher selectivity for NTS2 than for NTS1. NTRC-808 has antipsychotic and analgesic activity[1].
Product Specifications
CAS Number
1643879-88-2
UNSPSC
12352005
Target
Neurotensin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC(C)C[C@@H](C(O)=O)NC(C1=NC(C2=C(OC)C=CC=C2OC)=C3C=C(Cl)C=CC3=N1)=O
Molecular Formula
C23H24ClN3O5
Molecular Weight
457.91
References & Citations
[1]J. B. Thomas et al. Identification of N-{[6-chloro-4- (2,6-dimethoxyphenyl) quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2. Med. Chem. Lett. 25 (2015) 292-296.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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