NTRC-808

NTRC-808 is a nonpeptide selective GPCR neurotensin receptor type 2 (NTS2) partial agonist with an EC50 of 14 nM and Ki of 88 nM. NTRC-808 has higher selectivity for NTS2 than for NTS1. NTRC-808 has antipsychotic and analgesic activity[1].

Product Specifications

CAS Number

[1643879-88-2]

UNSPSC

12352005

Target

Neurotensin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CC(C)C[C@@H](C(O)=O)NC(C1=NC(C2=C(OC)C=CC=C2OC)=C3C=C(Cl)C=CC3=N1)=O

Molecular Formula

C23H24ClN3O5

Molecular Weight

457.91

References & Citations

[1]J. B. Thomas et al. Identification of N-{[6-chloro-4- (2,6-dimethoxyphenyl) quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2. Med. Chem. Lett. 25 (2015) 292-296.