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Zidovudine Glucuronide-13C6

Zidovudine Glucuronide-13C6 (3'-Azido-3'-deoxythymidine β-D-glucuronide-13C6) is 13C labeled Zidovudine O-β-D-glucuronide. Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection[1][2].

Product Specifications

Product Name Alternative

3'-Azido-3'-deoxythymidine β-D-glucuronide-13C6

UNSPSC

12352005

Target

Drug Metabolite; Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Smiles

O=C1N(C=C(C(N1)=O)C)[C@@H]2O[C@@H]([C@H](C2)N=[N+]=[N-])CO[13C@@]3O[13C@@]([13C@]([13C@@]([13C@]3O)O)O)[13C](O)=O

Molecular Formula

C10 13C6H16N5O10

Molecular Weight

444.28

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Fayz S, et, al. Zidovudine azido-reductase in human liver microsomes: activation by ethacrynic acid, dipyridamole, and indomethacin and inhibition by human immunodeficiency virus protease inhibitors. Antimicrob Agents Chemother. 1998 Jul;42 (7) :1654-8.|[3]Bélanger AS, et, al. Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine. Drug Metab Dispos. 2009 Sep;37 (9) :1793-6.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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