Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Sitagliptin (phosphate) (Standard)

Sitagliptin (MK-0431) phosphate (Standard) is the analytical standard of Sitagliptin phosphate. This product is intended for research and analytical applications. Sitagliptin phosphate is an orally active and highly selective DPP4 inhibitor with an IC50 value of 19 nM. Sitagliptin phosphate blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin phosphate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin phosphate shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin phosphate can be used for the study of 1-type and 2-type diabetes.

Product Specifications

CAS Number

654671-78-0

Product Name Alternative

MK-0431 (phosphate) (Standard)

UNSPSC

12352005

Target

Dipeptidyl Peptidase; Endogenous Metabolite; ERK; GLP Receptor; PKA; Reference Standards

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Metabolic Disease

Smiles

O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O)(O)O

Molecular Formula

C16H18F6N5O5P

Molecular Weight

505.31

References & Citations

[1]Thomas, L., et al. (R) -8- (3-amino-piperidin-1-yl) -7-but-2-ynyl-3-methyl-1- (4-methyl-quinazolin-2-ylm ethyl) -3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of acti|[2]Kim, S.J., et al., Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Diabetes, 2009. 58 (3) : p. 641-51.|[3]Sangle, G.V., et al., Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a glucagon-like peptide-1 secretagogue. Endocrinology, 2012. 153 (2) : p. 564-73.|[4]Kim, S.J., et al., Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice. Diabetes, 2008. 57 (5) : p. 1331-9.|[5]Beconi, M.G., et al. Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs. Drug Metab Dispos, 2007. 35 (4) : p. 525-32.|[6]Thomas, L., et al. (R) -8- (3-amino-piperidin-1-yl) -7-but-2-ynyl-3-methyl-1- (4-methyl-quinazolin-2-ylm ethyl) -3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of acti|[7]Kim, S.J., et al., Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Diabetes, 2009. 58 (3) : p. 641-51.|[8]Sangle, G.V., et al., Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a glucagon-like peptide-1 secretagogue. Endocrinology, 2012. 153 (2) : p. 564-73.|[9]Kim, S.J., et al., Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice. Diabetes, 2008. 57 (5) : p. 1331-9.|[10]Beconi, M.G., et al. Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs. Drug Metab Dispos, 2007. 35 (4) : p. 525-32.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

MYH15 Human Gene Knockout Kit (CRISPR)
KN415967 1 Kit

MYH15 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Cell Division Cycle 34 homolog (CPTC-CDC34-2), CF647 conjugate, 0.1mg/mL
BNC472267-100 1x 100 µL

Cell Division Cycle 34 homolog (CPTC-CDC34-2), CF647 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Phenanthrene-d10
TRC-P294801-1G 1 g

Phenanthrene-d10

Sign In for Pricing
View Details
4-Ethyl-N,N-diphenyl-1-naphthalenecarboxamide
TRC-E917380-50MG 50 mg

4-Ethyl-N,N-diphenyl-1-naphthalenecarboxamide

Sign In for Pricing
View Details
Bcl-6 (BCL6/850), CF594 conjugate, 0.1mg/mL
BNC940850-500 1x 500 µL

Bcl-6 (BCL6/850), CF594 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
NEK6 (NM_001166171) Human Over-expression Lysate
LC431305 20 µg

NEK6 (NM_001166171) Human Over-expression Lysate

Sign In for Pricing
View Details