TEAD-IN-1
TEAD-IN-1 (Compound 2) is potent TEAD autopalmitoylation inhibitor, with an IC50 of 603 nM. TEAD-IN-1 increases the interaction of TEAD and VGLL4. TEAD-IN-1 decreases the interaction of YAP and TEAD. TEAD-IN-1 can be used for the research of cancer[1][2].
Product Specifications
CAS Number
2412761-57-8
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
YAP
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Purity
99.43
Smiles
CS(=O)(NC1=CC(/C=C/C2CCC(F)(F)CC2)=C(OC)N=C1)=O
Molecular Formula
C15H20F2N2O3S
Molecular Weight
346.39
Precautions
H315, H319, H320
References & Citations
[1]Holden JK, et al. Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling. Cell Rep. 2020 Jun 23;31 (12) :107809. |[2]Guarnaccia A D, et al. TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway. bioRxiv, 2024: 2024.11. 15.623512.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TEAD
Available Sizes
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