KB-0742 (hydrochloride)

KB-0742 hydrochloride is a potent, selective and orally active CDK9 inhibitor with an IC50 of 6 nM for CDK9/cyclin T1. KB-0742 hydrochloride is selective for CDK9/cyclin T1 with >50-fold selectivity over other CDK kinases. KB-0742 hydrochloride has potent anti-tumor activity[1].

Product Specifications

UNSPSC

12352005

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

CCC(C1=NC2=CC=NN2C(N[C@@H]3C[C@H](CC3)N)=C1)CC.Cl

Molecular Formula

C16H26ClN5

Molecular Weight

323.86

References & Citations

[1]Freeman DB, et al. Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers. J Med Chem. 2023 Dec 14;66 (23) :15629-15647. |[2]André Richters, et al. Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors. Cell Chem Biol. 2020 Oct 20; S2451-9456 (20) 30380-9.