P-F-HHSiD (hydrochloride)

P-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a potent and selective M3 mAChR antagonist. p-F-HHSiD hydrochloride has antagonistic effects on other subtypes of the M receptor and the alpha1-adrenoceptor. p-F-HHSiD hydrochloride can be used for the researches of cancer, metabolic, neurological and cardiovascular disease such as, colon cancer, Alzheimer’s disease and diabetes[1][2][3][4][5][6].

Product Specifications

CAS Number

[175615-76-6]

Product Name Alternative

P-Fluorohexahydrosiladifenidol (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Adrenergic Receptor; mAChR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Metabolic Disease; Neurological Disease; Cardiovascular Disease

Purity

99.0

Smiles

O[Si](C1=CC=C(F)C=C1)(C2CCCCC2)CCCN3CCCCC3.[H]Cl

Molecular Formula

C20H33ClFNOSi

Molecular Weight

386.02

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Eglen RM, et al. Interaction of p-F-HHSiD (p-Fluoro-hexahydrosila-difenidol) at muscarinic receptors in guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342 (4) :394-9. |[2]Cheng K, et al. Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295 (3) :G591-7.|[3]Nishimaru K, et al. Positive and negative inotropic effects of muscarinic receptor stimulation in mouse left atria. Life Sci. 2000;66 (7) :607-15.|[4]Svensson AL, et al. Characterization of muscarinic receptor subtypes in Alzheimer and control brain cortices by selective muscarinic antagonists. Brain Res. 1992 Nov 20;596 (1-2) :142-8.|[5]He Y, et al. GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation. Sci Rep. 2025 Jul 7;15 (1) :24308.|[6]Shinoura H, et al. Antagonistic effects of antimuscarinic drugs on alpha 1-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 2002 Oct;366 (4) :368-71.