Phenoxodiol (Standard)

Phenoxodiol (Standard) is the analytical standard of Phenoxodiol. This product is intended for research and analytical applications. Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[1][2].

Product Specifications

CAS Number

[81267-65-4]

UNSPSC

12352100

Target

Apoptosis; Caspase; Reference Standards; Topoisomerase

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Smiles

OC1=CC=C2C=C(C3=CC=C(O)C=C3)COC2=C1

Molecular Formula

C15H12O3

Molecular Weight

240.25

References & Citations

[1]Kamsteeg M, et al. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. 2003 May 1;22 (17) :2611-20.|[2]Mahoney S, et al. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14 (1) :110.