(+) -Niguldipine

(+) -Niguldipine is a potent dual inhibitor targeting L-type Ca2+ channels (Ki=85 pM) and α₁-adrenoceptor (Ki=52 pM) . (+) -Niguldipine is promising for research of hypertension and cardiovascular diseases[1][2][3].

Product Specifications

CAS Number

[113165-32-5]

UNSPSC

12352005

Target

Adrenergic Receptor; Calcium Channel

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC=CC([N+]([O-])=O)=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3

Molecular Formula

C36H39N3O6

Molecular Weight

609.71

References & Citations

[1]Boer R, et al. (+) -Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of α1-adrenoceptors[J]. European Journal of Pharmacology: Molecular Pharmacology, 1989, 172 (2) : 131-145.|[2]Endoh M, et al. Effect of (+) -niguldipine on myocardial α1-adrenoceptors in the rabbit[J]. European journal of pharmacology, 1992, 223 (2-3) : 143-149.|[3]Charles Gluchowski, et al. Use of alpha-1c specific compounds to treat benign prostatic hyperplasia. WO1995028157A1. 1995-10-26.