(+) -Niguldipine
(+) -Niguldipine is a potent dual inhibitor targeting L-type Ca2+ channels (Ki=85 pM) and α₁-adrenoceptor (Ki=52 pM) . (+) -Niguldipine is promising for research of hypertension and cardiovascular diseases[1][2][3].
Product Specifications
CAS Number
113165-32-5
UNSPSC
12352005
Target
Adrenergic Receptor; Calcium Channel
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC=CC([N+]([O-])=O)=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3
Molecular Formula
C36H39N3O6
Molecular Weight
609.71
References & Citations
[1]Boer R, et al. (+) -Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of α1-adrenoceptors[J]. European Journal of Pharmacology: Molecular Pharmacology, 1989, 172 (2) : 131-145.|[2]Endoh M, et al. Effect of (+) -niguldipine on myocardial α1-adrenoceptors in the rabbit[J]. European journal of pharmacology, 1992, 223 (2-3) : 143-149.|[3]Charles Gluchowski, et al. Use of alpha-1c specific compounds to treat benign prostatic hyperplasia. WO1995028157A1. 1995-10-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
L-type calcium channel; α adrenergic receptor
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