S-1255
S-1255 is an orally active and highly selective endothelin ETA receptor antagonist (Kd=0.39 nM) . S-1255 blocks vasoconstriction and sustains hypotensive effects in hypertensive rats. S-1255 is promising for research of hypertension and cardiovascular disorders[1].
Product Specifications
CAS Number
203918-14-3
UNSPSC
12352005
Target
Endothelin Receptor
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
OC(C1=C(C2=CC=C(C=C2)OC)C3=CC(OC(C)C)=CC=C3O[C@@H]1C4=CC=C(OCO5)C5=C4)=O
Molecular Formula
C27H24O7
Molecular Weight
460.48
References & Citations
[1]Iwasaki T, et al. Pharmacologic characterization of S-1255, a highly potent and orally active endothelin A receptor antagonist. J Cardiovasc Pharmacol. 2001 Apr;37 (4) :471-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ETA
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