Rivaroxaban diol

Rivaroxaban diol is a metabolite of Rivaroxaban (HY-50903) . Rivaroxaban (BAY 59-7939) is a highly potent, selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM) [1][2][3].

Product Specifications

CAS Number

[1160170-00-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Cardiovascular Disease

Smiles

O=C(O1)N(C(C=C2)=CC=C2N(CCO)C(CO)=O)C[C@@H]1CNC(C(S3)=CC=C3Cl)=O

Molecular Formula

C19H20ClN3O6S

Molecular Weight

453.90

Precautions

P264-P270-P330-P501

References & Citations

[1]Lang D, et al. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans. Drug Metab Dispos. 2009 May;37 (5) :1046-55.|[2]Roehrig S, et al. Discovery of the novel antithrombotic agent 5-chloro-N- ({ (5S) -2-oxo-3- [4- (3-oxomorpholin-4-yl) phenyl]-1,3-oxazolidin-5-yl}methyl) thiophene- 2-carboxamide (BAY 59-7939) : an oral, direct factor Xa inhibitor. J Med Chem. 2005 Sep 22;48 (19) . |[3]Perzborn E, et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939--an oral, direct Factor Xa inhibitor. J Thromb Haemost. 2005 Mar;3 (3) :514-21.