Ac22 (Az8) 2

Ac22 (Az8) 2 is a selective BCRP inhibitor (EC50: 1-2 nM) . Ac22 (Az8) 2 can restore the drug sensitivity of BCRP-overexpressing cells by inhibiting BCRP-ATPase activity, blocking drug efflux, and increasing intracellular drug accumulation. Ac22 (Az8) 2 can be used in the research of BCRP-mediated multidrug-resistant cancers[1].

Product Specifications

CAS Number

[2377858-65-4]

UNSPSC

12352005

Target

BCRP

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C(OCC1=CC=CC(C(OC)=O)=C1)=C(C2=CC=C(OCCOCCN3N=NC(C4=CC(C5=CN(CCOCCOC6=CC=C(C7=C(OCC8=CC(C(OC)=O)=CC=C8)C(C(C=CC=C9)=C9O7)=O)C=C6)N=N5)=CC=C4)=C3)C=C2)O%10)C%11=C%10C=CC=C%11

Molecular Formula

C66H56N6O14

Molecular Weight

1157.18

References & Citations

[1]Zhu X, et al. Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors. J Med Chem. 2019 Sep 26;62 (18) :8578-8608.