Ac22 (Az8) 2
Ac22 (Az8) 2 is a selective BCRP inhibitor (EC50: 1-2 nM) . Ac22 (Az8) 2 can restore the drug sensitivity of BCRP-overexpressing cells by inhibiting BCRP-ATPase activity, blocking drug efflux, and increasing intracellular drug accumulation. Ac22 (Az8) 2 can be used in the research of BCRP-mediated multidrug-resistant cancers[1].
Product Specifications
CAS Number
2377858-65-4
UNSPSC
12352005
Target
BCRP
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C(OCC1=CC=CC(C(OC)=O)=C1)=C(C2=CC=C(OCCOCCN3N=NC(C4=CC(C5=CN(CCOCCOC6=CC=C(C7=C(OCC8=CC(C(OC)=O)=CC=C8)C(C(C=CC=C9)=C9O7)=O)C=C6)N=N5)=CC=C4)=C3)C=C2)O%10)C%11=C%10C=CC=C%11
Molecular Formula
C66H56N6O14
Molecular Weight
1157.18
References & Citations
[1]Zhu X, et al. Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors. J Med Chem. 2019 Sep 26;62 (18) :8578-8608.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC470276-100 1x 100 µL
TAG-72 / CA72.4 (B72.3), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740029-100 1x 100 µL
Fibronectin (TV-1), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC742479-100 1x 100 µL
CD3e (T-Cell Marker) (C3e/2479), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470061-100 1x 100 µL
Granulocyte Marker (BM-1), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880091-100 1x 100 µL
Fibronectin (2755-8), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details