1α-Hydroxyvitamin D5

1α-Hydroxyvitamin D5 (CARD-024) is a vitamin D analog with extremely low hypercalcemic effects. 1α-Hydroxyvitamin D5 effectively attenuates the pro-fibrotic response of colonic myofibroblasts to TGFβ and high-stiffness substrates by inhibiting the expression of αSMA, the phosphorylation of FAK, and the gene expression of MLCK and ET-1, while activating the anti-inflammatory pathway of IL-1β/COX-2. 1α-Hydroxyvitamin D5 can be used in research related to intestinal fibrosis associated with Crohn's disease[1].

Product Specifications

CAS Number

[187935-17-7]

Product Name Alternative

CARD-024

UNSPSC

12352211

Target

COX; FAK; Interleukin Related; Myosin

Related Pathways

Cytoskeleton; Immunology/Inflammation; Protein Tyrosine Kinase/RTK

Field of Research

Inflammation/Immunology

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](CC)C(C)C)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C

Molecular Formula

C29H48O2

Molecular Weight

428.69

References & Citations

[1]Johnson LA, et al. CARD-024, a vitamin D analog, attenuates the pro-fibrotic response to substrate stiffness in colonic myofibroblasts. Exp Mol Pathol. 2012 Aug;93 (1) :91-8.