PJ34 (hydrochloride) (Standard)
PJ34 (hydrochloride) (Standard) is the analytical standard of PJ34 (hydrochloride) . This product is intended for research and analytical applications. PJ34 hydrochloride is an inhibitor of PARP1/2 with IC50 of 110 nM and 86 nM, respectively.
Product Specifications
CAS Number
344458-15-7
UNSPSC
12352100
Target
PARP; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer
Smiles
O=C(NC(C=C1C2=C3C=CC=C2)=CC=C1NC3=O)CN(C)C.Cl
Molecular Formula
C17H18ClN3O2
Molecular Weight
331.80
References & Citations
[1]Iwashita A, et al. A novel and potent poly (ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3- (4-phenyl-3,6-dihydro-1 (2H) -pyridinyl) propyl]-4 (3H) -quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. J Ph|[2]Haddad M, et al. Anti-inflammatory effects of PJ34, a poly (ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. Br J Pharmacol. 2006 Sep;149 (1) :23-30.|[3]Diani-Moore S, et al. NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion. Sci Rep. 2017 May 23;7 (1) :2268.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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