CH0076989

CH0076989 is a specific CCR3 agonist. CH0076989 activates eosinophils and transfectants expressing both wild-type CCR3 and a CCR1:CCR3 chimaeric receptor lacking the CCR3 amino-terminus. CH0076989 has a direct interaction with the transmembrane helices of CCR3, supported by the complete loss of its activity due to mutations of the residues Y41, Y113 and E287. CH0076989 can be used for the study of inflammation and allergic diseases (such as asthma) [1].

Product Specifications

CAS Number

[954371-52-9]

UNSPSC

12352005

Target

CCR

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

BrC1=CC(NC(CC2=C3C=COC3=CC=C2)=O)=CC=[N+]1CCCC4=CC=CC=C4.[Br-]

Molecular Formula

C24H22Br2N2O2

Molecular Weight

530.25

References & Citations

[1]Wise EL, et al. Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation. J Biol Chem. 2007 Sep 21;282 (38) :27935-43.