Miltefosine (Standard)
Miltefosine (Standard) is the analytical standard of Miltefosine. This product is intended for research and analytical applications. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity[1][2][3][4]. Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) [5].
Product Specifications
CAS Number
58066-85-6
UNSPSC
12352100
Target
Akt; HIV; Parasite; Reference Standards
Related Pathways
Anti-infection; Others; PI3K/Akt/mTOR
Field of Research
Infection; Cancer
Smiles
O=P(OCC[N+](C)(C)C)(OCCCCCCCCCCCCCCCC)[O-]
Molecular Formula
C21H46NO4P
Molecular Weight
407.57
References & Citations
[1]Chugh P, et al. Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy. Retrovirology. 2008 Jan 31;5:11|[2]Uberall F, et al. Hexadecylphosphocholine inhibits inositol phosphate formation and protein kinase C activity. Cancer Res. 1991 Feb 1;51 (3) :807-12.|[3]Bhatt AP, et al. Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas. Blood. 2010 Jun 3;115 (22) :4455-63.|[4]Eissa MM, et al. Miltefosine Lipid Nanocapsules for Single Dose Oral Treatment of Schistosomiasis Mansoni: A Preclinical Study. PLoS One. 2015 Nov 17;10 (11) :e0141788|[5]de Freitas-Junior PR, et al. Effects of miltefosine on the proliferation, ultrastructure, and phospholipid composition of Angomonas deanei, a trypanosomatid protozoan that harbors a symbiotic bacterium. FEMS Microbiol Lett. 2012 Aug;333 (2) :129-37.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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