MeO-Suc-Ala-Ala-Pro-Ala-CMK

MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE), with an IC50 of 20.3 μM. MeO-Suc-Ala-Ala-Pro-Ala-CMK can inhibit the hydrolysis of substrates such as elastin in lung tissue by HNE. MeO-Suc-Ala-Ala-Pro-Ala-CMK can be used in the research of related diseases such as chronic obstructive pulmonary disease (COPD) [1].

Product Specifications

CAS Number

[111682-13-4]

Product Name Alternative

MSACK

UNSPSC

12352005

Target

Elastase

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(N[C@@H](C)C(CCl)=O)[C@H]1N(C([C@H](C)NC([C@H](C)NC(CCC(OC)=O)=O)=O)=O)CCC1

Molecular Formula

C20H31ClN4O7

Molecular Weight

474.94

References & Citations

[1]Zhang S, et al. Exploration of novel human neutrophil elastase inhibitors from natural compounds: Virtual screening, in vitro, molecular dynamics simulation and in vivo study. Eur J Pharmacol. 2024 Nov 5;982:176825.