N19-0881

N19-0881 (Compound 33) is an orally active, potent and selective KDM5A/5B histone lysine demethylase inhibitor (IC50= 0.013 μM and 0.002 μM, respectively) . N19-0881 is promising for research of epigenetically dysregulated tumors (e.g., breast cancer) [1].

Product Specifications

CAS Number

[1613410-75-5]

UNSPSC

12352005

Target

Histone Demethylase

Related Pathways

Epigenetics

Field of Research

Cancer

Smiles

O=C(C1=CC(N2N=CC=C2OCC3=CC=C(Cl)C=C3C)=NC=C1)O

Molecular Formula

C17H14ClN3O3

Molecular Weight

343.76

References & Citations

[1]Nie Z, et al. Structure-based design and discovery of potent and selective KDM5 inhibitors. Bioorg Med Chem Lett. 2018 May 15;28 (9) :1490-1494.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

KDM5

Curated Selection

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