SB 258741

SB 258741 is an efficient and highly selective 5-HT7 receptor (pKi = 8.5) antagonist. SB 258741 can be used for research on neurological disorders such as schizophrenia and depression[1].

Product Specifications

CAS Number

[201038-58-6]

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=S(N1[C@@H](CCN2CCC(C)CC2)CCC1)(C3=CC=CC(C)=C3)=O

Molecular Formula

C19H30N2O2S

Molecular Weight

350.52

References & Citations

[1]Pouzet B, et al. Effects of the 5-HT (7) receptor antagonist SB-258741 in animal models for schizophrenia. Pharmacol Biochem Behav. 2002 Apr;71 (4) :655-65. |[2]Mahé C, et al. Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors. Eur J Pharmacol. 2004 Jul 14;495 (2-3) :97-102.