2'-Deoxy-2'-fluoroadenosine 5'-triphosphate (tetralithium)
2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium is an ATP analog, it exerted a strong but mixed-type inhibition on poly (AU) synthesis.
Product Specifications
Product Name Alternative
AfTP (tetralithium), 2′-Fluoro-2′-deoxy-ATP (tetralithium)
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
F[C@@H]([C@@H]1N2C3=C(C(N)=NC=N3)N=C2)[C@H](O)[C@H](O1)COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O
Molecular Formula
C10H11FLi4N5O12P3
Molecular Weight
532.90
References & Citations
[1]Kasuya T, et, al. Highly accurate synthesis of the fully 2'-fluoro-modified oligonucleotide by Therminator DNA polymerases. Bioorg Med Chem Lett. 2014 May 1; 24 (9) : 2134-6.|[2]Ishihama A, Enami M, Nishijima Y, Fukui T, Ohtsuka E, Ikehara M. 2'-Deoxy-2'-azidoadenosine triphosphate and 2'-deoxy-2'-fluoroadenosine triphosphate as substrates and inhibitors for Escherichia coli DNA-dependent RNA polymerase. J Biochem. 1980;87 (3) :825-830.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Frequently Asked Questions
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