2'-Deoxy-2'-fluoroadenosine 5'-triphosphate (tetralithium)

2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium is an ATP analog, it exerted a strong but mixed-type inhibition on poly (AU) synthesis.

Product Specifications

Product Name Alternative

AfTP (tetralithium), 2′-Fluoro-2′-deoxy-ATP (tetralithium)

UNSPSC

12352005

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Solubility

10 mM in DMSO

Smiles

F[C@@H]([C@@H]1N2C3=C(C(N)=NC=N3)N=C2)[C@H](O)[C@H](O1)COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O

Molecular Formula

C10H11FLi4N5O12P3

Molecular Weight

532.90

References & Citations

[1]Kasuya T, et, al. Highly accurate synthesis of the fully 2'-fluoro-modified oligonucleotide by Therminator DNA polymerases. Bioorg Med Chem Lett. 2014 May 1; 24 (9) : 2134-6.|[2]Ishihama A, Enami M, Nishijima Y, Fukui T, Ohtsuka E, Ikehara M. 2'-Deoxy-2'-azidoadenosine triphosphate and 2'-deoxy-2'-fluoroadenosine triphosphate as substrates and inhibitors for Escherichia coli DNA-dependent RNA polymerase. J Biochem. 1980;87 (3) :825-830.