A-420983
A-420983 is a potent, orally active inhibitor of Lck and can be used in studies involving animal models of delayed-type hypersensitivity and organ transplant rejection[1].
Product Specifications
CAS Number
330789-03-2
UNSPSC
12352005
Target
Src
Related Pathways
Protein Tyrosine Kinase/RTK
Smiles
O=C(C(N1C)=CC2=C1C=CC=C2)NC3=CC=C(C4=NN([C@H]5CC[C@H](N6CCN(C)CC6)CC5)C7=NC=NC(N)=C74)C=C3OC
Molecular Formula
C33H39N9O2
Molecular Weight
593.72
References & Citations
[1]Borhani DW, et al. A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection. Bioorg Med Chem Lett. 2004;14 (10) :2613-2616.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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