MT-21
MT-21 is an Apoptosis inducer and adenine nucleotide translocase inhibitor. MT-21 induces Apoptosis by activating JNK via the Krs/MST protein. MT-21 activates caspase-3 via caspase-9. MT-21 induces the release of cytochrome c. MT-21 can be used in the research of tumors[1][2].
Product Specifications
CAS Number
186379-49-7
UNSPSC
12352005
Target
Apoptosis; Caspase; JNK
Related Pathways
Apoptosis; MAPK/ERK Pathway
Field of Research
Cancer
Smiles
O=C1N(CCCCCCCC)C(C)(O)C(C)=C1C(C)=O
Molecular Formula
C16H27NO3
Molecular Weight
281.39
References & Citations
[1]Watabe M, Machida K, Osada H. MT-21 is a synthetic apoptosis inducer that directly induces cytochrome c release from mitochondria. Cancer Res. 2000 Sep 15;60 (18) :5214-22.|[2]Machida K, et al. A novel adenine nucleotide translocase inhibitor, MT-21, induces cytochrome c release by a mitochondrial permeability transition-independent mechanism. J Biol Chem. 2002 Aug 23;277 (34) :31243-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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