MT-21

MT-21 is an Apoptosis inducer and adenine nucleotide translocase inhibitor. MT-21 induces Apoptosis by activating JNK via the Krs/MST protein. MT-21 activates caspase-3 via caspase-9. MT-21 induces the release of cytochrome c. MT-21 can be used in the research of tumors[1][2].

Product Specifications

CAS Number

[186379-49-7]

UNSPSC

12352005

Target

Apoptosis; Caspase; JNK

Related Pathways

Apoptosis; MAPK/ERK Pathway

Field of Research

Cancer

Smiles

O=C1N(CCCCCCCC)C(C)(O)C(C)=C1C(C)=O

Molecular Formula

C16H27NO3

Molecular Weight

281.39

References & Citations

[1]Watabe M, Machida K, Osada H. MT-21 is a synthetic apoptosis inducer that directly induces cytochrome c release from mitochondria. Cancer Res. 2000 Sep 15;60 (18) :5214-22.|[2]Machida K, et al. A novel adenine nucleotide translocase inhibitor, MT-21, induces cytochrome c release by a mitochondrial permeability transition-independent mechanism. J Biol Chem. 2002 Aug 23;277 (34) :31243-8.