Indibulin (Standard)

Indibulin (Standard) is the analytical standard of Indibulin. This product is intended for research and analytical applications. Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis[1].

Product Specifications

CAS Number

[204205-90-3]

UNSPSC

12352100

Target

Apoptosis; Microtubule/Tubulin; Reference Standards

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Others

Field of Research

Cancer; Neurological Disease

Smiles

O=C(NC1=CC=NC=C1)C(C2=CN(CC3=CC=C(Cl)C=C3)C4=C2C=CC=C4)=O

Molecular Formula

C22H16ClN3O2

Molecular Weight

389.83

References & Citations

[1]Kapoor S, et al. Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy. Sci Rep. 2018 Aug 17;8 (1) :12363.