Buspirone N-oxide
Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone (HY-B1115A) . Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research[1][2].
Product Specifications
CAS Number
[220747-81-9]
Product Name Alternative
Bu N-oxide
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Drug Metabolite
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(N(CCCC[N+]1([O-])CCN(C2=NC=CC=N2)CC1)C(C3)=O)CC43CCCC4
Molecular Formula
C21H31N5O3
Molecular Weight
401.50
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Zhu M, et al. Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab Dispos. 2005 Apr;33 (4) :500-7. |[2]Kim JK, et, al. Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice. Sci Rep. 2021 Mar 17;11 (1) :6094.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor
Curated Selection
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