4-Epianhydrotetracycline (hydrochloride)
4-Epianhydrotetracycline hydrochloride is a major intermediate product of Tetracycline. 4-Epianhydrotetracycline hydrochloride shows lethal effects and induces cell apoptosis of zebrafish embryos. 4-Epianhydrotetracycline hydrochloride inhibits Shewanella, E. coli and P. aeruginosa with MIC values of 2, 1 and 64 mg/L, respectively[1].
Product Specifications
CAS Number
4465-65-0
UNSPSC
12352005
Target
Antibiotic; Apoptosis; Bacterial
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
O[C@@](C(C1=C(C2=C3O)O)=O)(C(C(C(N)=O)=C4O)=O)[C@](CC1=C(C2=CC=C3)C)([H])[C@H]4N(C)C.Cl
Molecular Formula
C22H23ClN2O7
Molecular Weight
462.88
References & Citations
[1]Wang M, et al. Effects of 4-epianhydrotetracycline on oxidative stress in zebrafish (Danio rerio) embryos. Sci Total Environ. 2021 Nov 20;796:149047.|[2]Wang M, et al. Developmental toxicity and transcriptome analysis of 4-epianhydrotetracycline to zebrafish (Danio rerio) embryos. Sci Total Environ. 2020 Sep 10;734:139227. |[3]Long S, et al. Toxicity of tetracycline and its transformation products to a phosphorus removing Shewanella strain. Chemosphere. 2020 May;246:125681.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Tetracycline
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