3'-Hydroxy simvastatin

3'-Hydroxy simvastatin is a metabolite of simvastatin. Simvastatin (HY-17502) is an orally active competitive inhibitor of HMG-CoA reductase (HMGCR) (Ki: 0.2 nM) [1].

Product Specifications

CAS Number

[1283861-33-5]

UNSPSC

12352005

Target

Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Smiles

[H][C@@]1([C@H](C=CC2=C[C@@H](C[C@@H]([C@@]21[H])OC(C(C)(C(O)C)C)=O)C)C)CC[C@@]3([H])OC(C[C@@H](C3)O)=O

Molecular Formula

C25H38O6

Molecular Weight

434.57

References & Citations

[1]Slater EE, et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs. 1988;36 Suppl 3:72-82.