21-Acetoxypregna-1,4,9 (11),16-tetraene-3,20-dione
21-Acetoxypregna-1,4,9 (11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone. The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization[1].
Product Specifications
CAS Number
37413-91-5
UNSPSC
12352211
Hazard Statement
H302, H312, H315, H319, H332, H335, H361
Target
Glucocorticoid Receptor; NF-κB
Related Pathways
Immunology/Inflammation; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@](CC=C2C(COC(C)=O)=O)([H])[C@@]3([H])C([C@@]4(C(CC3)=CC(C=C4)=O)C)=CC1
Molecular Formula
C23H26O4
Molecular Weight
366.45
Precautions
H302, H312, H315, H319, H332, H335, H361
References & Citations
[1]Erica K M Reeves, et al. VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid. Bioorg Med Chem
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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