β-D-tetraacetylgalactopyranoside-PEG1-N3
β-D-tetraacetylgalactopyranoside-PEG1-N3 is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. β-D-tetraacetylgalactopyranoside-PEG1-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
153252-36-9
UNSPSC
12352203
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.0
Solubility
10 mM in DMSO
Smiles
CC(O[C@H]([C@H]([C@@H]1OCCOCCN=[N+]=[N-])OC(C)=O)[C@H]([C@H](O1)COC(C)=O)OC(C)=O)=O
Molecular Formula
C18H27N3O11
Molecular Weight
461.42
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Glycosidase Cleavable Linker
Available Sizes
Frequently Asked Questions
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