N1, N11-Diethylnorspermine (tetrahydrochloride)
Selected Variant
HY-13610A-01
Size: 5 mg
N1, N11-Diethylnorspermine tetrahydrochloride (DENSPM tetrahydrochloride) is a potent anticancer agent. N1, N11-Diethylnorspermine tetrahydrochloride activates polyamine catabolism and downregulates mTOR protein. N1, N11-Diethylnorspermine tetrahydrochloride induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1, N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production[1][2][3][4][5][6].
Product Specifications
CAS Number
156886-85-0
Product Name Alternative
Diethylnorspermine (tetrahydrochloride) ; DENSPM (tetrahydrochloride) ; BENSPM (tetrahydrochloride)
UNSPSC
12352211
Target
Caspase; mTOR
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Purity
99.82
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
CCNCCCNCCCNCCCNCC.[H]Cl.[H]Cl.[H]Cl.[H]Cl
Molecular Formula
C13H36Cl4N4
Molecular Weight
390.26
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3
Available Sizes
Price
Frequently Asked Questions
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