Methyltetrazine-PEG4-hydrazone-DBCO
Methyltetrazine-PEG4-hydrazone-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Methyltetrazine-PEG4-hydrazone-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-PEG4-hydrazone-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
Product Specifications
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
90.0
Solubility
10 mM in DMSO
Smiles
O=C(CCC(N/N=C\C1=CC=C(C(NCCOCCOCCOCCOCCC(NCC2=CC=C(C3=NN=C(C)N=N3)C=C2)=O)=O)C=C1)=O)N4C5=CC=CC=C5C#CC6=CC=CC=C6C4
Molecular Formula
C48H51N9O8
Molecular Weight
881.97
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Acid Cleavable Linker; Cleavable Linker
Available Sizes
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