Tetrazine-diazo-PEG4-biotin
Tetrazine-diazo-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Tetrazine-diazo-PEG4-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
Product Specifications
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
OC(C(/N=N/C1=CC=C(C(NCC2=CC=C(C3=NN=CN=N3)C=C2)=O)C=C1)=C4)=CC=C4CCNC(CCOCCOCCOCCOCCNC(CCCC[C@H]5[C@@H](NC(N6)=O)[C@@H]6CS5)=O)=O
Molecular Formula
C45H57N11O9S
Molecular Weight
928.07
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Frequently Asked Questions
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