Dacinostat (Standard)
Dacinostat (Standard) is the analytical standard of Dacinostat. This product is intended for research and analytical applications. Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.
Product Specifications
CAS Number
404951-53-7
UNSPSC
12352100
Target
Autophagy; HDAC; Reference Standards
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer
Smiles
O=C(NO)/C=C/C1=CC=C(CN(CCO)CCC2=CNC3=C2C=CC=C3)C=C1
Molecular Formula
C22H25N3O3
Molecular Weight
379.45
References & Citations
[1]Atadja P, et al. Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824. Cancer Res. 2004 Jan 15;64 (2) :689-95.|[2]Cho YS, et al. Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824) . J Med Chem. 2010 Apr 8;53 (7) :2952-63.|[3]Romanski A, et al. Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells. Cell Cycle. 2012 Sep 1;11 (17) :3219-26.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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